HCID 67794837, compound → HCID 67796793, compound

Participants

Reaction Steps

A solution of 400 mg of 5-[3-(2-methoxycarbonylethyl)-4-[6-(4-methoxyphenyl)-(5E)-5-hexenyloxy]-phenyl]-5-oxo-pentanoic acid methyl ester in 33 ml of methanol and 13 ml of in sodium hydroxide solution is stirred for 16 hours at room temperature. The methanol is distilled off in a vacuum, the alkaline solution is acidified with in hydrochloric acid to pH 1, shaken out with ethyl acetate, the organic phase is dried on sodium sulfate and concentrated by evaporation. 272 mg of the title compound of the melting point of 113°-114° is obtained.

Provenance & Evidence