(1E)-6-bromo-1-(4-methoxyphenyl)-1-hexene → HCID 67795002, compound

Participants

Reaction Steps

Under the conditions of example 1A, 640 mg of 3-[5-(6-methoxycarbonyl-2-pyridylcarbonyl)-2-hydroxyphenyl]-propionic acid methyl ester is reacted with 505 mg of (1E)-6-bromo-l-(4-methoxyphenyl)- 1-hexene, worked up and the crude product chromatographed on silica gel with hexane/ethyl acetate (0-15%). 732 mg of 3-{5-[6-methoxycarbonyl-2-pyridylcarbonyl]-2-[6-(4-methoxyphenyl)-(5E)-5-hexenyloxy]-phenyl}-propionic acid methyl ester of melting point 80°-82° C. is obtained.

Provenance & Evidence