Lithium Carbonate → 5-(3-hydroxy-4-[6-(4-methoxyphenyl)-(5E)-5-hexenyloxy]-phenyl}-5-oxopentanoic acid methyl ester

Participants

Reaction Steps

Under the conditions of example 2C, 1.8g of 5-(3,4-dihydroxyphenyl)-5-oxo-pentanoic acid methyl ester in 19 ml of dimethylformamide is reacted in the presence of 1.4g of lithium carbonate with 2.05g of (1E)-6-bromo-1-(4-methoxyphenyl)-1-hexene, worked up and chromatographed. 470 mg of 5-(3-hydroxy-4[6-(4-methoxyphenyl)-(5E)-5-hexenyloxy]-phenyl)-5-oxo-pentanoic acid methyl ester of melting point 78°-80° C. is obtained.

Provenance & Evidence