huagongshe.com
HRID1707324

反应详情

EQUATION

反应方程式

HRID 1707324 的结构方程式

REACTANTS

反应物

1
结构：CN(C)C=O.N[C@@H](C(=O)N[C@@H]1C(=O)N2C(C(=O)O)=C(Cl)CC[C@H]12)c1ccccc1
HCID86748173

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)=O.N[C@@H](C(=O)N[C@@H]1C(=O)N2C(C(=O)O)=C(Cl)CC[C@H]12)c1ccccc1
HCID86748172

未命名化合物

收率 101.5%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC(C)=O
溶剂HCID180

Acetone

C3H6O

PROCEDURE

实验过程

Loracarbef DMF disolvate 7.0 g (50 bg) was slurried in 50 ml acetone for 15 minutes (no noticeable change under microscope). The crystals were filtered on a 5.5 cm Buchner funnel with a Whatman 1 filter (fast filtration). The crystals were washed with ~7 ml acetone. The crystals were dried in the vacuum oven for two hours at 45° C. Wgt: 5.66 g, Purity: 90.4%, DMF: 3.15%, KF: 4.3%, Rel. Subs: 0.23%, Yield: 101.5%

WORKUP

后处理

  1. filtrationThe crystals were filtered on a 5.5 cm Buchner funnel with a Whatman 1
  2. filtrationfilter
  3. filtration(fast filtration)
  4. washThe crystals were washed with ~7 ml acetone
  5. customThe crystals were dried in the vacuum oven for two hours at 45° C