Sodium Hydroxide → HCID 10347845, compound

Participants

Reaction Steps

N-[2(R)-(t-butoxycarbonyl)amino-3-triphenylmethylmercaptopropyl]-L-isoleucine methyl ester (1.63 g, 0.0028 mol) was dissolved in MeOH (50 mL) and 1N NaOH solution (11.23 mL, 0.0112 mol) was added with stirring at ambient temperature. After 4 h,.solid NaOH (2.0 g) was added and stirring was continued for 16 h. The reaction mixture was concentrated to remove MeOH and extracted with EtOAc (2×100 mL). The extract was washed with brine and dried (Na2SO4). Filtration and concentration to dryness gave 1.6 g of the title compound.

Provenance & Evidence