4-acetyl-5-oxohexanenitrile → HCID 18963356, compound

HRID 1707342Notes

Reaction equation

HRID 1707342 reaction equation
[C:1]([CH:4]([C:9](=O)[CH3:10])[CH2:5][CH2:6][C:7]#[N:8])(=[O:3])[CH3:2].[H][H]>C(O)C.[Ni]>[C:1]([C:4]1[CH2:5][CH2:6][CH2:7][NH:8][C:9]=1[CH3:10])(=[O:3])[CH3:2]

Participants

5

Reactant 2

HCID 4237844-acetyl-5-oxohexanenitrileHCID 178418361HCID 178418361, compound

Product 1

HCID 18963356HCID 18963356, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 702EthanolSolvent

Procedure

A solution of 4,4-diacetylbutyronitrile (15.3 g, 0.1 mole) in ethyl alcohol (50 ml) over Raney nickel (2 g) was hydrogenated at room temperature and three atmospheres pressure. After hydrogen uptake had ceased, the catalyst was filtered off and the filtrate concentrated under reduced pressure to give 3-acetyl-2-methyl-1,4,5,6-tetrahydropyridine.

Workup

  1. customwas hydrogenated at room temperature
  2. filtrationthe catalyst was filtered off
  3. concentrationthe filtrate concentrated under reduced pressure

Sources & evidence

ORD record
ord-538607f49d3848078520479147bc6f28
Source dataset
uspto-grants-1994_10
Patent number
US05352793

Reaction notes

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