1-Chloro-4-iodobutane → HCID 19003599, compound

HRID 1707380Notes

Reaction equation

HRID 1707380 reaction equation
[Li].[N:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH2:8][C:9]2[CH:16]=[CH:15][C:12]([C:13]#[N:14])=[CH:11][CH:10]=2)[CH:3]=1.Cl[CH2:18][CH2:19][CH2:20][CH2:21]I>>[C:13]([C:12]1[CH:15]=[CH:16][C:9]([C:8]2([C:4]3[CH:3]=[N:2][CH:7]=[CH:6][CH:5]=3)[CH2:21][CH2:20][CH2:19][CH2:18]2)=[CH:10][CH:11]=1)#[N:14]

Participants

4

Reactant 3

HCID 825271-Chloro-4-iodobutaneHCID 3028194LithiumHCID 142311684-[(Pyridin-3-yl)methyl]benzonitrile

Product 1

HCID 19003599HCID 19003599, compound

Procedure

Using procedure described in Example 36, the lithium salt of 4-(3-pyridylmethyl)-benzonitrile is treated with 1-chloro-4-iodobutane and the intermediate cyclized to obtain 1-(4-cyanophenyl)-1-(3-pyridyl)-cyclopentane.

Sources & evidence

ORD record
ord-35b6c4bddc3d4819a1d6cd76bf840d65
Source dataset
uspto-grants-1994_10
Patent number
US05352795

Reaction notes

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