Water → HCID 10037300, compound

Participants

Reaction Steps

A mixture of 65.1g (0.45 mol)of E-4-phenyl-3-buten-2-one, 50 g (0.45 mol)of 2-thiophenecarboxaldehyde, 4 mL of aqueous 10% sodium hydroxide, 50 mL of water, and 75 mL of ethanol was stirred at ambient temperature for 15 hours. The solid which separated was collected by filtration and air dried to give 85.6 g (80% yield) of E,E- 1-(2-thienyl)-5-phenyl- 1,4-pentadien-3-one as a yellow solid. 1H NMR, IR, and FDMS analyses were consistent with the expected structure.

Provenance & Evidence