Hydrochloric Acid → HCID 9975616, compound

Participants

Reaction Steps

To a suspension of litium aluminum hydride (1.07 g: 28.2 mMol.) in tetrahydrofuran (100 ml) under ice cooling is added 4-acetylthiomethyl-1-trityl-1,2,3-triazole (7.50 g: 18.8 mMol.), and the mixture is stirred at room temperature for 40 minutes. To the reaction mixture is added aqueous tetrahydrofuran dropwise, and the mixture is neutralized with 10% hydrochloric acid. The solution is filtered and the filtrate is diluted with ethyl acetate, washed with brine, dried over sodium sulfate, and concentrated. The residue is crystallized from ether and washed with ether to give 1-trityl-1,2,3-triazol-4-ylmethylmercaptan (5.14 g) as white crystals. Yield: 77%. mp. 140° to 141° C.

Provenance & Evidence