反应详情

34 g (0.19 mol) of trans-4-butylcyclohexylacetonitrile, 43 g (0.76 mol) of KOH, 34 cm3 of water and 190 cm3 of ethanol were refluxed on a hot water bath until formation of ammonia gas stopped. The ethanol in the reactant was removed, the residue was dissolved in 100 cm3 of water, it was poured into a beaker containing 100 cm3 of concentrated HCl and 100 g of ice, and the deposited crystals were filtered and washed in water. The crystals were recrystallized from a solvent mixture of methanol and water to obtain 37 g (0.19 mol) of trans-4-butylcyclohexylacetic acid.

1. customThe ethanol in the reactant was removed
2. dissolutionthe residue was dissolved in 100 cm3 of water
3. additionit was poured into a beaker
4. additioncontaining 100 cm3 of concentrated HCl and 100 g of ice
5. filtrationthe deposited crystals were filtered
6. washwashed in water
7. customThe crystals were recrystallized from a solvent mixture of methanol and water