反应详情

31 g (0.17 mol) of 2-(trans-4'-butylcyclohexyl)ethanol was given dropwise addition of 23 g (0.09 mol) of PBr3 while stirring at room temperature, after which it was stirred for 1 hour on a 70° C. hot water bath. The reactant was cooled to room temperature, poured into ice water to decompose the excess PBr3, the oily layer was taken off, and the water layer was extracted with chloroform and combined with the oily layer and washed with water. The chloroform was removed, and the remaining oily substance was distilled under reduced pressure (b. p. 99° C./2 mmHg) to obtain 32 g (0.13 mol) of 2-(trans-4'-butylcyclohexyl)-1-bromoethane.

1. stirringafter which it was stirred for 1 hour on a 70° C. hot water bath
2. temperatureThe reactant was cooled to room temperature
3. extractionthe water layer was extracted with chloroform
4. washwashed with water
5. customThe chloroform was removed
6. distillationthe remaining oily substance was distilled under reduced pressure (b. p. 99° C./2 mmHg)