Sodium Methoxide → HCID 18961504, compound

Participants

Reaction Steps

1.0 g (3.1 mM) of 2-octyl-6-amidino-1-indanone hydrochloride, 0.38 g (7.0 mM) of sodium methylate, 0.78 g (3.26 mM) of α-decyl-β-dimethylaminoacrolein and 10 ml of methanol were placed in a 10 ml-round bottomed flask, followed by refluxing for 17 hours under stirring. After the reaction, the reaction mixture was cooled on an ice water bath to precipitate a crystal. The crystal was recovered by filtration and purified by silica gel column chromatography (eluent: toluene/ethyl acetate=100/1), followed by recrystallization from a mixture solvent (toluene/methanol) to obtain 0.59 g of 2-octyl-6-(5-decylpyrimidine-2-yl)-1-indanone (Yield: 41%, m.p.=83° C.).

Provenance & Evidence