HCID 18961527, compound → HCID 18961521, compound

Participants

Reaction Conditions

Reaction Steps

0.4 g (0.88 mM) of 2-[4-(5-decylpyrimidine-2-yl)benzyl]octanoic acid and 1.3 g of polyphosphoric acid were placed in a flask, followed by stirring for 6 hours at 130° C. After the reaction, 10 ml of water was added to the reaction mixture, followed by extraction with toluene. The extract was dried, followed by distilling-off of the solvent to obtain a crude product. The crude product was purified by silica gel column chromatography (eluent: toluene/ethyl acetate=100/1) and recrystallized from a mixture solvent (toluene/methanol) to obtain 0.25 g (0.57 mM) of 2-hexyl-6-(5-decylpyrimidine-2-yl)-1-indanone (Yield: 65%, m.p.=87° C.).

Provenance & Evidence