Sodium Acetate → HCID 18961635, compound

HRID 1707555Notes

Reaction equation

HRID 1707555 reaction equation
C([O:4][C:5]1[CH:23]=[CH:22][CH:21]=[CH:20][C:6]=1[C:7]([NH:9][C:10]1[CH:11]=[CH:12][C:13]2[O:17][C:16]([CH3:18])=[N:15][C:14]=2[CH:19]=1)=[O:8])(=O)C.C([O-])(=O)C.[Na+]>CO>[OH:4][C:5]1[CH:23]=[CH:22][CH:21]=[CH:20][C:6]=1[C:7]([NH:9][C:10]1[CH:11]=[CH:12][C:13]2[O:17][C:16]([CH3:18])=[N:15][C:14]=2[CH:19]=1)=[O:8]

Participants

4

Reactant 2

HCID 517045Sodium AcetateHCID 18961634HCID 18961634, compound

Product 1

HCID 18961635HCID 18961635, compoundYield 84%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

5-(2-Acetoxybenzamido)-2-methylbenzoxazole (10.0 g, 0.032 mol) was combined with sodium acetate (3.5 g, 0.043 mol) in 100 mL of MeOH and the solution was heated to reflux for 2.5 hr. The heat source was removed and after standing for 2 hours the mixture was chilled in a refrigerator overnight. The solid was collected and dried affording 7.2 g (84% yield) of product; m.p. 202°-206° C.

Workup

  1. temperaturethe solution was heated
  2. temperatureto reflux for 2.5 hr
  3. customThe heat source was removed
  4. temperaturethe mixture was chilled in a refrigerator overnight
  5. customThe solid was collected
  6. customdried

Sources & evidence

ORD record
ord-8165fc9dc1fc4a98a01e7adb4ed53158
Source dataset
uspto-grants-1994_10
Patent number
US05354651

Reaction notes

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