反应详情

A solution of 1.47 g (7.32 mmol) of (3) in 90 mL of methanol was hydrogenated over 200 mg of 5% Pd/CaCO3 at 5 psi hydrogen over a 1.2 hour period. After removing the catalyst by filtration and evaporation of the solvent in vacuo, the residue was triturated with ether followed by hexane which afforded a white solid: m.p. 101°-102° C.

1. customAfter removing the catalyst
2. filtrationby filtration and evaporation of the solvent in vacuo
3. customthe residue was triturated with ether
4. customafforded a white solid