Piperazine, 1-propyl-, hydrochloride (1:2) → HCID 15224908, compound

HRID 1707625Notes

Reaction equation

HRID 1707625 reaction equation
[Cl:1][C:2]1[CH:19]=[CH:18][C:5]2[O:6][C:7]3[CH:17]=[CH:16][CH:15]=[CH:14][C:8]=3[CH2:9][N:10]([C:11](Cl)=[O:12])[C:4]=2[CH:3]=1.[CH2:20]([N:23]1[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]1)[CH2:21][CH3:22]>>[Cl:1][C:2]1[CH:19]=[CH:18][C:5]2[O:6][C:7]3[CH:17]=[CH:16][CH:15]=[CH:14][C:8]=3[CH2:9][N:10]([C:11]([N:26]3[CH2:27][CH2:28][N:23]([CH2:20][CH2:21][CH3:22])[CH2:24][CH2:25]3)=[O:12])[C:4]=2[CH:3]=1

Participants

3

Reactant 2

HCID 415812Piperazine, 1-propyl-, hydrochloride (1:2)HCID 149759838-chlorodibenz[b,f][1,4]oxazepin-10(11H)carbonyl chloride

Product 1

HCID 15224908HCID 15224908, compoundYield 88.4%

Procedure

The title compound of Example 2 (1.0 g, 3.4 mmol) was combined with 1-propylpiperazine (0.44 g, 3.4 mmol) and the reaction was carried out by the method of Example 4. Following chromatographic purification, 1.16 g of the title product was obtained as a white solid.

Workup

  1. custompurification

Sources & evidence

ORD record
ord-898c398b1c0c428091484e36118acbac
Source dataset
uspto-grants-1994_10
Patent number
US05354747

Reaction notes

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