3-(Pyridin-3-yl)propanoic acid → HCID 15289274, compound

HRID 1707643Notes

Reaction equation

HRID 1707643 reaction equation
[Cl:1][C:2]1[CH:25]=[CH:24][C:5]2[O:6][C:7]3[CH:23]=[CH:22][CH:21]=[CH:20][C:8]=3[CH2:9][N:10]([C:11]([N:13]3[CH2:19][CH2:18][CH2:17][NH:16][CH2:15][CH2:14]3)=[O:12])[C:4]=2[CH:3]=1.[N:26]1[CH:31]=[CH:30][CH:29]=[C:28]([CH2:32][CH2:33][C:34](O)=[O:35])[CH:27]=1>>[Cl:1][C:2]1[CH:25]=[CH:24][C:5]2[O:6][C:7]3[CH:23]=[CH:22][CH:21]=[CH:20][C:8]=3[CH2:9][N:10]([C:11]([N:13]3[CH2:19][CH2:18][CH2:17][N:16]([C:34](=[O:35])[CH2:33][CH2:32][C:28]4[CH:27]=[N:26][CH:31]=[CH:30][CH:29]=4)[CH2:15][CH2:14]3)=[O:12])[C:4]=2[CH:3]=1

Participants

3

Reactant 2

HCID 2596243-(Pyridin-3-yl)propanoic acidHCID 15289265HCID 15289265, compound

Product 1

HCID 15289274HCID 15289274, compoundYield 61.1%

Procedure

The title compound of Example 60 (0.73 g, 2.0 mmol) was coupled to 3-(3-pyridyl) propanoic acid (0.31 g, 2.0 mmol) by the procedure of Example 55. Following chromatographic separation of the crude product, 0.60 g of the title compound was obtained as a white solid and used in Example 87 without further purification.

Workup

  1. customseparation of the crude product

Sources & evidence

ORD record
ord-f001a906bb74473283f1681ee63a36c3
Source dataset
uspto-grants-1994_10
Patent number
US05354747

Reaction notes

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