N-Benzyl-2-(piperazin-1-yl)ethan-1-amine → HCID 15224927, compound

HRID 1707647Notes

Reaction equation

HRID 1707647 reaction equation
[Cl:1][C:2]1[CH:19]=[CH:18][C:5]2[O:6][C:7]3[CH:17]=[CH:16][CH:15]=[CH:14][C:8]=3[CH2:9][N:10]([C:11](Cl)=[O:12])[C:4]=2[CH:3]=1.[C:20]1([CH2:26][NH:27][CH2:28][CH2:29][N:30]2[CH2:35][CH2:34][NH:33][CH2:32][CH2:31]2)[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>>[Cl:1][C:2]1[CH:19]=[CH:18][C:5]2[O:6][C:7]3[CH:17]=[CH:16][CH:15]=[CH:14][C:8]=3[CH2:9][N:10]([C:11]([N:33]3[CH2:34][CH2:35][N:30]([CH2:29][CH2:28][NH:27][CH2:26][C:20]4[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=4)[CH2:31][CH2:32]3)=[O:12])[C:4]=2[CH:3]=1

Participants

3

Reactant 2

HCID 14900561N-Benzyl-2-(piperazin-1-yl)ethan-1-amineHCID 149759838-chlorodibenz[b,f][1,4]oxazepin-10(11H)carbonyl chloride

Product 1

HCID 15224927HCID 15224927, compoundYield 44.5%

Procedure

The title compound of Example 2 (0.72 g, 2.45 mmol) was combined with N-(phenylmethyl)-1-piperazineethanamine (0.75 g, 3.40 mmol) and the reaction was carried out by the method of Example 4. Following chromatographic separation, 0.52 g of the white solid title product was obtained.

Workup

  1. customseparation

Sources & evidence

ORD record
ord-b4ce36dd43524445a522db139a311b1d
Source dataset
uspto-grants-1994_10
Patent number
US05354747

Reaction notes

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