1-(2-Furylmethyl)piperazine → 1-[(8-chlorodibenz[b,f][1,4]thiazepin-10(11H)-yl)carbonyl]-4-(2-furanylmethyl)piperazine

HRID 1707651Notes

Reaction equation

HRID 1707651 reaction equation
[Cl:1][C:2]1[CH:19]=[CH:18][C:5]2[S:6][C:7]3[CH:17]=[CH:16][CH:15]=[CH:14][C:8]=3[CH2:9][N:10]([C:11](Cl)=[O:12])[C:4]=2[CH:3]=1.[O:20]1[CH:24]=[CH:23][CH:22]=[C:21]1[CH2:25][N:26]1[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]1>>[Cl:1][C:2]1[CH:19]=[CH:18][C:5]2[S:6][C:7]3[CH:17]=[CH:16][CH:15]=[CH:14][C:8]=3[CH2:9][N:10]([C:11]([N:29]3[CH2:30][CH2:31][N:26]([CH2:25][C:21]4[O:20][CH:24]=[CH:23][CH:22]=4)[CH2:27][CH2:28]3)=[O:12])[C:4]=2[CH:3]=1

Participants

3

Reactant 2

HCID 7647161-(2-Furylmethyl)piperazineHCID 229217168-chlorodibenz[b,f][1,4]thiazepine-10(11H)-carbonyl chloride

Product 1

HCID 193775931-[(8-chlorodibenz[b,f][1,4]thiazepin-10(11H)-yl)carbonyl]-4-(2-furanylmethyl)piperazine

Procedure

The title compound of Example 105 is reacted with the product of Example 63 by the method of Example 4. Following chromatographic separation, the title product is obtained.

Workup

  1. customseparation

Sources & evidence

ORD record
ord-899a5c396a184dcd84a591934c9360d2
Source dataset
uspto-grants-1994_10
Patent number
US05354747

Reaction notes

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