Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Ammonium Chloride | HCID 25517 | — |
| Reactant | 2-Nitro-4-phenylmethoxyanisole | HCID 15676976 | — |
| Catalyst | Zinc | HCID 23994 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 5-(Benzyloxy)-2-methoxyaniline | HCID 15676978 | — |
Reaction Steps
1.38 kg of zinc powder and 15 g of ammonium chloride in 3.25 litres of ethanol to which have been added 600 ml of water are heated to 80° C. 2.5 mole (648 g) of 3-benzyloxy-6-methoxynitrobenzene is added little by little. Stirring is continued for 15 minutes after the end of the addition. The zinc is removed by filtering the reaction medium hot. The product crystallizes from the filtrate by cooling. After centrifuging and then washing with petrol ether, the product is dried. It melts at 81° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05354870 |
|---|
| Source dataset | uspto-grants-1994_10 |
|---|
| ORD ID | ord-514b1587b89f4067abed8272e6917800 |
|---|
| Source note | uspto-grants-1994_10 |
|---|
