5-(4'-(Bromomethyl)(1,1'-biphenyl)-2-yl)-1-trityl-1H-tetraazole → HCID 178456435, compound

HRID 1707768Notes

Reaction equation

HRID 1707768 reaction equation
[CH2:1]([N:4]1[C:8]([C:9]#[C:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[C:7]([CH:17]=[O:18])[N:6]=[CH:5]1)[CH2:2][CH3:3].Br[CH2:20][C:21]1[CH:26]=[CH:25][C:24]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=2[C:33]2[N:37](C(C3C=CC=CC=3)(C3C=CC=CC=3)C3C=CC=CC=3)[N:36]=[N:35][N:34]=2)=[CH:23][CH:22]=1>>[C:11]1([C:10]#[C:9][C:8]2[N:4]([CH2:1][CH2:2][CH3:3])[CH2:5][N:6]([CH2:20][C:21]3[CH:26]=[CH:25][C:24]([C:27]4[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=4[C:33]4[NH:34][N:35]=[N:36][N:37]=4)=[CH:23][CH:22]=3)[C:7]=2[CH:17]=[O:18])[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

Participants

3

Reactant 2

HCID 100534615-(4'-(Bromomethyl)(1,1'-biphenyl)-2-yl)-1-trityl-1H-tetraazoleHCID 54409322HCID 54409322, compound

Product 1

HCID 178456435HCID 178456435, compound

Procedure

3-n-Propyl-4-(phenylethynyl)imidazole-5-carboxaldehyde was alkylated with 4-bromomethyl-2'-(N-triphenylmethyl-(1H-tetrazol-5-yl))biphenyl by the procedure described in example 1, parts D and I, to yield the entitled product. NMR (CDCl3) δ 9.88 (s,1H): 8.03 (m,1H); 7.57-7.27 (m,8H); 7.17 (m,2H); 7.01 (m,2H); 5.55 (s,2H); 2.61 (t,2H); 1.75 (m,2H); 0.99 (t,3H).

Workup

  1. customto yield the entitled product

Sources & evidence

ORD record
ord-3825ce28544d40838800a165b9397e3a
Source dataset
uspto-grants-1994_10
Patent number
US05354867

Reaction notes

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