5-Acetoxyacetamido-3-methylcarbamoyl2,4,6-triiodobenzoyl chloride → N-(2,3-dihydroxypropyl)-5-[2,3-diacetoxypropionylamino)-N'-methyl-2,4,6-triiodoisophthalamide

HRID 1707905Notes

Reaction equation

HRID 1707905 reaction equation
[C:1]([O:4][CH:5]([CH2:25][O:26][C:27](=[O:29])[CH3:28])[C:6]([NH:8]C1C(I)=C(C(=O)NC)C(I)=C(C=1I)C(Cl)=O)=[O:7])(=[O:3])[CH3:2].[OH:30][CH:31]([CH2:57][OH:58])[CH2:32][N:33](NC(=O)C)[C:34](=[O:52])[C:35]1[C:44]([I:45])=[C:43](OC(=O)C)[C:42]([I:50])=[C:37]([C:38]([NH:40][CH3:41])=[O:39])[C:36]=1[I:51].C(OCC(NC1C(I)=C(C(=O)NC)C(I)=C(C=1I)C(Cl)=O)=O)(=O)C>>[OH:30][CH:31]([CH2:57][OH:58])[CH2:32][NH:33][C:34](=[O:52])[C:35]1[C:44]([I:45])=[C:43]([NH:8][C:6](=[O:7])[CH:5]([O:4][C:1](=[O:3])[CH3:2])[CH2:25][O:26][C:27](=[O:29])[CH3:28])[C:42]([I:50])=[C:37]([C:38]([NH:40][CH3:41])=[O:39])[C:36]=1[I:51]

Participants

4

Reactant 3

HCID 156706225-Acetoxyacetamido-3-methylcarbamoyl2,4,6-triiodobenzoyl chlorideHCID 189602905-(2,3-Diacetoxypropionylamino)-3-methylcarbamoyl-2,4,6-triiodobenzoyl chlorideHCID 86748190N-(2,3-dihydroxypropyl)-5-acetoxy-acetamido-N'-methyl-2,4,6-triiodoisophthalamide

Product 1

HCID 86748189N-(2,3-dihydroxypropyl)-5-[2,3-diacetoxypropionylamino)-N'-methyl-2,4,6-triiodoisophthalamide

Procedure

Compound (12) is prepared from compound (11) in the same manner according to the procedure described for the preparation of compound (4) from compound (3) in Example I, C.

Sources & evidence

ORD record
ord-ac0a11267a894de5a74ba0a74983a8be
Source dataset
uspto-grants-1994_10
Patent number
US05356613

Reaction notes

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