Acetic Acid → 3-(5-acetylamino-4-chloro-2-fluorophenyl)-1-methyl-6-trifluoromethyl-2,4(1H,3H)-pyrimidinedione

HRID 1707939Notes

Reaction equation

HRID 1707939 reaction equation
[NH2:1][C:2]1[C:3]([Cl:22])=[CH:4][C:5]([F:21])=[C:6]([N:8]2[C:13](=[O:14])[CH:12]=[C:11]([C:15]([F:18])([F:17])[F:16])[N:10]([CH3:19])[C:9]2=[O:20])[CH:7]=1.[C:23](O)(=[O:25])[CH3:24]>C1C=CC=CC=1>[C:23]([NH:1][C:2]1[C:3]([Cl:22])=[CH:4][C:5]([F:21])=[C:6]([N:8]2[C:13](=[O:14])[CH:12]=[C:11]([C:15]([F:18])([F:17])[F:16])[N:10]([CH3:19])[C:9]2=[O:20])[CH:7]=1)(=[O:25])[CH3:24]

Participants

4

Reactant 2

HCID 176Acetic AcidHCID 186192573-(5-amino-4-chloro-2-fluorophenyl)-1-methyl-6-trifluoromethyl-2,4(1H,3H)-pyrimidinedione

Product 1

HCID 183659043-(5-acetylamino-4-chloro-2-fluorophenyl)-1-methyl-6-trifluoromethyl-2,4(1H,3H)-pyrimidinedione

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

In 5 ml of benzene was dissolved 2.00 g of 3-(5-amino-4-chloro-2-fluorophenyl)-1-methyl-6-trifluoromethyl-2,4(1H,3H)-pyrimidinedione, and 0.61 ml of anhydrous acetic acid was added thereto and the mixture was refluxed for one hour. Benzene was removed by distillation to obtain a crude product. This was washed with hexane to obtain 2.20 g of the desired compound as white crystal.

Workup

  1. additionwas added
  2. temperaturethe mixture was refluxed for one hour
  3. customBenzene was removed by distillation
  4. customto obtain a crude product
  5. washThis was washed with hexane

Sources & evidence

ORD record
ord-0147dbab9e5445ff8d4071426911fee4
Source dataset
uspto-grants-1994_10
Patent number
US05356863

Reaction notes

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