5-prop-2-enyl-1H-pyrimidine-2,4-dione → HCID 14914594, compound

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Reaction Steps

To a solution of 5-allyluracil (80 mg; 0.5 mmol) in 95% aq. EtOH (50 ml) was added (Ph3P)3RhCl (90 mg; 0.1 mmol) and the mixture heated under reflux for 3 days. The solvent was evaporated and the product isolated by flash chromatography on SiO2 eluted with 5% MeOH-CH2Cl2. Yield 56 mg 70%; 200 MHz 1H-NMR DMSO-d6, δ:11.0 (br s, 1H, NH); 7.42 (s, 1H, 6-H); 6.35-6.55 (qq, 1H =CH--Me); 5.95-6.1 (dd, 1H, --CH=); 1.74 (dd, 3H, CH3).

Provenance & Evidence