Acetic Anhydride → HCID 15730044, compound

Participants

Reaction Steps

A solution of 7-amino-2-(2-furyl)-5-phenoxy-[1,2,4]triazolo[1,5-a][1,3,5]triazine (950 mg) in acetic anhydride was heated under reflux for 1.5 hours. The solvent was then evaporated in vacuo and the residue was purified by chromatography on silica eluting with dichloromethane containing ethyl acetate (5% v/v). The amorphous solid thereby obtained was crystallised from toluene to give 7-acetylamino-2-(2-furyl)-5-phenoxy-[1,2,4]-triazolo[1,5-a][1,3,5]triazine as colourless prisms, m.p. 168°-170° C.; microanalysis, found; C, 60.9; H, 4.2; N, 22.6%; C16H12N6O3 0.45 C7H8 requires: C, 60.9; H, 4.1; N, 22.3%; NMR 2.3 (s, 3H equivalent, toluene CH3), 2.35 (s, 3H, CH3CO), 6.7 (q, 1H, furyl-4H), 7.1-7.6 (complex, 6H, furyl-3H+ phenyl-H+toluene), 7.95(d, 1H, furyl-5H), 11.5 (broad s, 1H, NH); m/e 336 (M+).

Provenance & Evidence