Sodium Bicarbonate → HCID 178524784, compound

Participants

Reaction Steps

A mixture of 4,7-dihydro-6-ethoxycarbonyl-2- (4-fluorophenyl)-3-(pyridin-4-yl)-7-oxopyrazolo [1,5-a ] pyrimidine (946 mg) in sulfuric acid (40% in water, 5 ml) was refluxed for 2 hours. After cooling, the pH of the reaction mixture was adjusted to 5 with an aqueous saturated sodium bicarbonate solution. The crude crystalline was obtained and washed with hot ethanol to give 4,7-dihydro-6-carboxy-2-(4-fluorophenyl)-3-(pyridin-4-yl)-7-oxopyrazolo[1,5-a]pyrimidine (275 mg).

Provenance & Evidence