Nitrogen mustard hydrochloride → HCID 18958756, compound

Participants

Reaction Steps

A mixture of 2-fluoro-5-nitrobenzenamine (4.06 g) and 2-chloro-N-(2-chloroethyl)-N-methylethanamine hydrochloride (5.006 g) in chlorobenzene (20 ml) was heated at reflux under nitrogen for 21/2 days. The dark solid was dissolved in methanol (150 ml) and the solution was then concentrated in vacuo onto silica and purified by FCC eluting with System A (400:8:1) to give impure material (1.9 g). This was purified again by FCC eluting with System A (300:8:1) to give the title compound as a crystalline brown solid (360 mg).

Provenance & Evidence