Azetidine → HCID 18960567, compound

HRID 1708073Notes

Reaction equation

[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[CH:4][C:3]=1[CH3:11].S(Cl)(Cl)=O.[NH:16]1[CH2:19][CH2:18][CH2:17]1>>[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([N:16]2[CH2:19][CH2:18][CH2:17]2)=[O:8])=[CH:4][C:3]=1[CH3:11]

Participants

Reactant 3

HCID 10422Azetidine

HCID 24386Thionyl Chloride

HCID 821314-Bromo-3-methylbenzoic acid

Product 1

HCID 18960567HCID 18960567, compound

Procedure

From 4-bromo-3-methylbenzoic acid (400 mg), thionyl chloride (0.5 ml) and azetidine (1 g).

Sources & evidence

ORD record: ord-37371e34dc0342e0b46f6b4b0c585586
Source dataset: uspto-grants-1994_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05356893

Reaction notes

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