Carbonochloridic acid, 4-methoxyphenyl ester → HCID 53889674, compound

HRID 1708113Notes

Reaction equation

HRID 1708113 reaction equation
[CH3:1][O:2][N:3]=[C:4]([C:7]1[CH2:8][NH:9][CH2:10][CH2:11][CH:12]=1)[C:5]#[N:6].[CH3:13][O:14][C:15]1[CH:20]=[CH:19][C:18]([O:21][C:22](Cl)=[O:23])=[CH:17][CH:16]=1>>[CH3:1][O:2][N:3]=[C:4]([C:7]1[CH2:8][N:9]([C:22]([O:21][C:18]2[CH:19]=[CH:20][C:15]([O:14][CH3:13])=[CH:16][CH:17]=2)=[O:23])[CH2:10][CH2:11][CH:12]=1)[C:5]#[N:6]

Participants

3

Reactant 2

HCID 82128Carbonochloridic acid, 4-methoxyphenyl esterHCID 54399635HCID 54399635, compound

Product 1

HCID 53889674HCID 53889674, compoundYield 85.6%

Procedure

α-(Methoxyimino)-α-(1,2,5,6-tetrahydropyridin-3-yl)acetonitrile (D8) (0.5 g, 0.003 moles) was treated with 4-methoxyphenylchloroformate (0.5 ml, 0.0033 moles) as in the method of Example 1. The crude produce was triturated with pentane to give the title compound (E4) as a white crystalline solid (0.81 g, 85%) m.p. 75°-76° C.

Workup

  1. customThe crude produce
  2. customwas triturated with pentane

Sources & evidence

ORD record
ord-8e25a8e0387c4f4a887c6c7d99864b87
Source dataset
uspto-grants-1994_10
Patent number
US05356914

Reaction notes

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