Propyl isocyanate → HCID 53865558, compound

Participants

Reaction Steps

Propyl isocyanate (0.23 g, 0.00275 moles) was added to a solution of α-(methoxyimino)-α-(1-hydroxy-1,2,5,6-tetrahydropyridin-3-yl)acetonitrile (E2) (0.45 g, 0.0025 moles ) in dry toluene (20 ml) with stirring. The mixture was kept at ambient temperature for 2 hrs then evaporated to dryness. The resulting residue crystallised from ethyl acetate/60-80 petrol. Recrystallisation from the same solvent system gave the title compound (E8) as a white crystalline solid (0.37 g, 56%) m.p. 95°-6° C.

Provenance & Evidence