Phenyl isocyanate → HCID 53903353, compound

Participants

Reaction Steps

α-(Methoxyimino)-α-(1-hydroxy-1,2,5,6-tetrahydropyridin-3-yl)acetonitrile (E2) (0.45 g, 0.0025 moles) was treated with phenyl isocyanate as in the method of Example 8. The residue obtained was chromatographed on silica gel eluting with 0-1% methanol/chloroform to give a crystalline solid. Recrystallisation from ethyl acetate/60-80 petrol gave the title compound (E9) as white crystals (0.245 g, 33%) m.p. 128°-130° C.

Provenance & Evidence