反应详情

4.9 g (25 mmol) of 6-butyl-2-oxo-1,2-dihydro-isonicotinic acid are boiled under reflux (237° C.) for 1.5 h with 1.79 g (12.5 mmol) of copper (I) oxide in 50 ml of quinoline. After filtering off, the volatile constituents are removed by distillation in vacuo (110° C. at 17 mbar, then 67° C. at 9 mbar). The residue is chromatographed twice on silica gel using dichloromethane/methanol (40:1)→(20:1) and the product is stirred in petroleum ether.

1. filtrationAfter filtering off
2. customthe volatile constituents are removed by distillation in vacuo (110° C. at 17 mbar
3. custom67° C.
4. customThe residue is chromatographed twice on silica gel