Ammonia → 6-Butyl-4-carbamoyl-2-oxo-1,2-dihydropyridine

HRID 1708146Notes

Reaction equation

HRID 1708146 reaction equation
[CH2:1]([C:5]1[NH:10][C:9](=[O:11])[CH:8]=[C:7]([C:12]([O:14]C)=O)[CH:6]=1)[CH2:2][CH2:3][CH3:4].[NH3:16]>C(O)C>[CH2:1]([C:5]1[NH:10][C:9](=[O:11])[CH:8]=[C:7]([C:12](=[O:14])[NH2:16])[CH:6]=1)[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 2

HCID 222Ammonia2×HCID 152251016-Butyl-4-methoxycarbonyl-2-oxo-1,2-dihydropyridine

Product 1

HCID 189608186-Butyl-4-carbamoyl-2-oxo-1,2-dihydropyridine

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

3 g (14.3mmol) of the compound from Example 1 are heated for a few minutes in 10 ml of ethanol and 20 ml of conc. ammonia. A further 5 ml of conc. ammonia are then added three times each and the mixture is again briefly heated to boiling. After cooling, the precipitate is filtered off with suction and dried over P2O5 in vacuo.

Workup

  1. temperatureis again briefly heated to boiling
  2. temperatureAfter cooling
  3. filtrationthe precipitate is filtered off with suction
  4. dry with materialdried over P2O5 in vacuo

Sources & evidence

ORD record
ord-62b55189dfa94ea3981f2520f962ecf7
Source dataset
uspto-grants-1994_10
Patent number
US05356911

Reaction notes

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