HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethyl benzylidenemalonate → 5-Ethoxycarbonyl-3-methoxycarbonyl-2-oxo-4-phenyl-6-propyl-1,2,3,4-tetrahydropyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethyl benzylidenemalonate | HCID 245906 | — |
| Reactant | Sodium ethoxide | HCID 2723922 | — |
| Reactant | Ethyl 3-amino-hex-2-enoate | HCID 85320704 | — |
| Product | 5-Ethoxycarbonyl-3-methoxycarbonyl-2-oxo-4-phenyl-6-propyl-1,2,3,4-tetrahydropyridine | HCID 23352079 | — |
Reaction Steps
26.2 g (0.128 mol) of dimethyl benzylidenemalonate and 20.1 g (0.128 mol) of ethyl-3-amino-hex-2-en-oate are stirred at 140° C. for 3 days with a spatula tip full of sodium ethoxide. The mixture is chromatographed on silica gel using methylene chloride and crystallised from petroleum ether.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05356911 |
| Source dataset | uspto-grants-1994_10 |
| ORD ID | ord-9a8bce40277f4188aed0b6a0a97e0fa4 |
| Source note | uspto-grants-1994_10 |