Hydrochloric Acid → HCID 9817496, compound

Participants

Reaction Steps

A solution containing 13.0 g (0.039 mol) methyl 3-(3-cyclopentyloxy-4-methoxyphenyl)-4-nitrobutanoate prepared above in 400 ml tetrahydrofuran containing 4 ml water was gradually added to 3.8 g aluminium foil treated before with a solution of mercuric chloride (1 g) in water. The temperature was held at 15°-20° C. by cooling. The mixture was stirred overnight at ambient temperature after which toluene and 200 ml 6N hydrochloric acid were added. The organic phase was separated and washed with 0.8M sodium hydrogen carbonate solution and evaporated to dryness in vacuo. The residue was crystallized from a mixture of dichloromethane-ether. Yield 1.7 g (15 mp 126°-130° C.

Provenance & Evidence