Phosphorus oxide (P4O10) → HCID 23184801, compound

HRID 1708156Notes

Reaction equation

HRID 1708156 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[O:11][CH:10]([CH2:12][CH2:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[CH:9]([C:20]3[N:21]([CH3:25])[CH:22]=[CH:23][N:24]=3)[CH:8](O)[C:7]=2[CH:27]=1.O=P12OP3(OP(OP(O3)(O1)=O)(=O)O2)=O>C1C=CC=CC=1>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[O:11][CH:10]([CH2:12][CH2:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[C:9]([C:20]3[N:21]([CH3:25])[CH:22]=[CH:23][N:24]=3)=[CH:8][C:7]=2[CH:27]=1

Participants

4

Reactant 2

HCID 14812Phosphorus oxide (P4O10)HCID 54385941HCID 54385941, compound

Product 1

HCID 23184801HCID 23184801, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

By proceeding analogously similar 2-substituted 3-(1-methyl-1H-imidazol-2-yl) 2H-1-benzopyran-6-ols can be prepared. The above 6-methoxy-2-(2-phenylethyl)-3-(1-methyl-1H-imidazol-2-yl) 2H-1-benzopyran is prepared by refluxing for 2 hours a mixture of 6-methoxy-2-(2-phenylethyl)-3-(1-methyl-1H-imidazol-2-yl) 2,3-dihydro-4H-1-benzopyran-4-ol (2 g) (prepared following the procedure described in J. Het. Chem. (1984) 21, 311), phosphorous pentoxide (2 g) and Amberlite® 1R 122 (20 mg) in anhydrous benzene (200 ml).

Workup

  1. customcan be prepared
  2. temperatureby refluxing for 2 hours
  3. customprepared

Sources & evidence

ORD record
ord-d3febb726b8a48f5946490f93260f0cc
Source dataset
uspto-grants-1994_10
Patent number
US05356920

Reaction notes

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