4-Amino-1-butanol → HCID 54320074, compound

HRID 1708199Notes

Reaction equation

[O:1]=[C:2]1[NH:6][C@H:5]([C:7]([OH:9])=O)[CH2:4][S:3]1.[OH:10][CH2:11][CH2:12][CH2:13][CH2:14][NH2:15]>>[OH:10][CH2:11][CH2:12][CH2:13][CH2:14][NH:15][C:7]([C@@H:5]1[CH2:4][S:3][C:2](=[O:1])[NH:6]1)=[O:9]

Participants

Reactant 2

HCID 258684-Amino-1-butanol

HCID 72390Procysteine

Product 1

HCID 54320074HCID 54320074, compoundYield 41.3%

Procedure

Following a procedure similar to that described in Example 16(a), but using 1.2 g of (4R)-2-oxothiazolidine-4-carboxylic acid and 2.23 g of N-(4-hydroxybutyl)amine, 0.735 g of the title compound was obtained as colorless crystals, melting at 81°-83° C.

Sources & evidence

ORD record: ord-33b2e17c53e3492f8d482efbdcffd4ce
Source dataset: uspto-grants-1994_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05356918

Reaction notes

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