HCID 10446373, compound → HCID 10037749, compound

Participants

Reaction Steps

A mixture of 3-(1-methylethoxy) -5-nitrobenzo[b]-thiophene-2-carboxamide (104 mg, 0.37 mmol) and 5% Pd on carbon (10 mg) in 20 mL of acetic acid is hydrogenated for 1.5 hours. The catalyst is removed by filtration and the filtrate concentrated in vacuo. The crude product is chromatograhed, eluting with 1:2 hexane:ethyl acetate, providing 62 mg of 5-amino-3-(1-methylethoxy)benzo[b]thiophene-2-carboxamide (67%); mp 150°-151° C.

Provenance & Evidence