4-Thiazoleacetic acid, 2-amino-, ethyl ester → HCID 18961214, compound

HRID 1708218Notes

Reaction equation

HRID 1708218 reaction equation
[CH3:1][O:2][C:3]1[CH:18]=[CH:17][C:6]2[S:7][C:8]([C:14]([OH:16])=O)=[C:9]([O:10][CH:11]([CH3:13])[CH3:12])[C:5]=2[CH:4]=1.[CH2:19]([O:21][C:22](=[O:30])[CH2:23][C:24]1[N:25]=[C:26]([NH2:29])[S:27][CH:28]=1)[CH3:20]>>[CH3:1][O:2][C:3]1[CH:18]=[CH:17][C:6]2[S:7][C:8]([C:14]([NH:29][C:26]3[S:27][CH:28]=[C:24]([CH2:23][C:22]([O:21][CH2:19][CH3:20])=[O:30])[N:25]=3)=[O:16])=[C:9]([O:10][CH:11]([CH3:12])[CH3:13])[C:5]=2[CH:4]=1

Participants

3

Reactant 2

HCID 1044544-Thiazoleacetic acid, 2-amino-, ethyl esterHCID 139616485-Methoxy-3-(1-methylethoxy)benzo[b]thiophene-2-carboxylic acid

Product 1

HCID 18961214HCID 18961214, compoundYield 73%

Procedure

Following a procedure analogous to Example 2, 5-methoxy-3-(1-methylethoxy)benzo[b]thiophene-2-carboxylic acid (1.033 g, 3.88 mmol) and ethyl-2-amino-4-thiazoleacetate (709 mg, 4.37 mmol) gives 1.22 g (73%) of product; mp 91°-92° C.

Sources & evidence

ORD record
ord-8ac87ddf31ab456ebae3f9319810266b
Source dataset
uspto-grants-1994_10
Patent number
US05356926

Reaction notes

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