P-Cresol → HCID 18961263, compound

Participants

Reaction Steps

A mixture of 41.6 g (0.39 mol) of p-cresol and 29.0 g (0.13 mol) of 4-carboxymethoxymandelic acid is maintained at 185° C. under a nitrogen atmosphere for 90 minutes, during which the water formed is distilled off. Excess p-cresol is then distilled off under reduced pressure. Crystallisation of the residue from 75 ml of xylene gives 31.4 g (81%) of 3-(4-carboxymethoxyphenyl)-5-methylbenzofuran-2-one, melting point 198°-203° C. (compound (101), Table 1).

Provenance & Evidence