p-Toluenesulfonic acid → HCID 18961269, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 5.0 g (18.5 mmol) of 1-octadecanol, 5.0 g (16.8 mmol) of 3-(4-carboxymethoxyphenyl)-5-methylbenzofuran-2-one (Compound (101), Example 1) and 1.0 g (5.3 mmol) of p-toluenesulfonic acid is stirred at 200° C. under a slight vacuum (150 mmHg) for about 1 hour. The reaction mixture is then diluted with 60 ml of ligroin and cooled with ice/water. The precipitated product is filtered. Crystallisation of the residue due from ligroin given 7.5 g (81%) of 5-methyl-3-(4-n-octadecyloxycarbonylmethoxyphenyl)benzofuran-2-one, melting pint 85°-87° C. (Compound (105), Table 1).

Provenance & Evidence