HCID 14627257, compound → HCID 14627258, compound

HRID 1708363Notes

Reaction equation

HRID 1708363 reaction equation
[C:1]([NH:4][C:5]([CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[C:19]([CH3:23])[C:18]=1[N+:24]([O-])=O)([C:11]([O:13][CH2:14][CH3:15])=[O:12])[C:6](OCC)=[O:7])(=[O:3])[CH3:2]>C(O)(=O)C.[Pd]>[C:1]([NH:4][C:5]1([C:11]([O:13][CH2:14][CH3:15])=[O:12])[CH2:16][C:17]2[C:18](=[C:19]([CH3:23])[CH:20]=[CH:21][CH:22]=2)[NH:24][C:6]1=[O:7])(=[O:3])[CH3:2]

Participants

4

Reactant 1

HCID 14627257HCID 14627257, compound

Product 1

HCID 14627258HCID 14627258, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 176Acetic AcidSolvent

Procedure

10 Grams of diethyl 2-acetylamino-2-(2-nitro-3-methylbenzyl)malonate and 1 g of 10% Pd-C were suspended in 50 ml of acetic acid, and the suspension was catalytically reduced under 3 to 3.5 atmospheric pressure at 60° to 70° C. by hydrogenation. After the hydrogenation was finished, the catalyst was removed by filtration, and the solvent was removed by evaporation. The residue thus obtained was recrystallized from ethanol to obtain 2.7 g of ethyl 3-acetylamino-8-methyl-3,4-dihydrocarbostyril-3-carboxylate. White powdery substance. Melting point: 236.5°-238.5° C.

Workup

  1. customwas catalytically reduced under 3 to 3.5 atmospheric pressure at 60° to 70° C. by hydrogenation
  2. customthe catalyst was removed by filtration
  3. customthe solvent was removed by evaporation
  4. customThe residue thus obtained
  5. customwas recrystallized from ethanol

Sources & evidence

ORD record
ord-1a8553ff6af94cebade1ac4f507e3f3a
Source dataset
uspto-grants-1994_10
Patent number
US05358949

Reaction notes

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