1-(2-Methoxyphenyl)piperazine → 1-(2-methoxy-5-nitrophenyl)piperazine

Participants

Reaction Steps

Potassium nitrate (6.06 g) was added portionwise during 2 h to a solution of 1-(2-methoxyphenyl)piperazine ( 10.0 g) in sulphuric acid (50 ml; 95%) at room temperature. The resulting brown solution was stirred at room temperature for 30 min and added cautiously to ice (300 ml). The solution was basified with aqueous sodium hydroxide (5N) and extracted with ethyl acetate (2×400 ml). The dried extract was evaporated and the residue was purified on a column of silica (190:10:1) to give the title compound as a yellow solid (9.4 g). m.p. 102°-104° C.

Provenance & Evidence