HuagongsheHuagongshe Chemistry Print Report · For research reference only
Nitrogen mustard hydrochloride → 4-(2-Butoxyphenyl)-1-methylpiperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Nitrogen mustard hydrochloride | HCID 5935 | — |
| Reactant | 2-Butoxyaniline | HCID 138265 | — |
| Solvent | Chlorobenzene | HCID 7964 | — |
| Product | 4-(2-Butoxyphenyl)-1-methylpiperazine | HCID 18958772 | 99% |
Reaction Steps
A stirred solution of 2-butoxybenzenamine (6.50 g) in chlorobenzene (50 ml) was treated with 2-chloro-N-(2-chloroethyl)-N-methylethanamine hydrochloride (7.70 g) according to the method of Intermediate 40. Concentration in vacuo of the dichloromethane extracts gave the title compound as a red oil (9.67 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05358948 |
| Source dataset | uspto-grants-1994_10 |
| ORD ID | ord-8fd85a8eb43243149d0d1916c1f52a82 |
| Source note | uspto-grants-1994_10 |