Ethyl orthoformate → HCID 10474143, compound

HRID 1708407Notes

Reaction equation

HRID 1708407 reaction equation
[CH2:1]([C:4]1[N:9]=[C:8]([CH3:10])[N:7]=[C:6]([NH:11][NH2:12])[C:5]=1[CH2:13][C:14]1[CH:19]=[CH:18][C:17]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=2[C:26]#[N:27])=[CH:16][CH:15]=1)[CH2:2][CH3:3].[CH:28](OCC)(OCC)OCC>>[CH2:1]([C:4]1[N:9]=[C:8]([CH3:10])[N:7]2[CH:28]=[N:12][N:11]=[C:6]2[C:5]=1[CH2:13][C:14]1[CH:19]=[CH:18][C:17]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=2[C:26]#[N:27])=[CH:16][CH:15]=1)[CH2:2][CH3:3]

Participants

3

Reactant 2

HCID 31214Ethyl orthoformateHCID 10473537HCID 10473537, compound

Product 1

HCID 10474143HCID 10474143, compound

Procedure

20 g of 6-n-propyl-2-methyl-4-hydrazino-5-[(2'-cyano-4-biphenylyl)methyl]pyrimidine, prepared in Example 12, are heated to reflux for 6 hours in 200 ml of triethyl orthoformate. The mixture is then concentrated under vacuum and the residue is taken up with ether. The crystals obtained are drained and washed with ether to give 18.8 g of 7-n-propyl-5-methyl-8-[(2'-cyano-4-biphenylyl)methyl]-1,2,4-triazolo[4,3-c]pyrimidine in the form of crystals of melting point 153° C.

Workup

  1. temperatureare heated
  2. concentrationThe mixture is then concentrated under vacuum
  3. customThe crystals obtained
  4. washwashed with ether

Sources & evidence

ORD record
ord-18e3a33413d84c98be7d7b300709c857
Source dataset
uspto-grants-1994_10
Patent number
US05358950

Reaction notes

Loading…