Ethylene Glycol → HCID 10251334, compound

Participants

Reaction Steps

8 g of 7-n-butyl-5-methyl-8-[(2'-cyano-4-biphenylyl)methyl]-1,2,4-triazolo[1,5-c]pyrimidin-2(3H)-one, prepared in Example 111, are heated to reflux for 10 hours in a solution of 6 g of sodium hydroxide in 30 ml of ethylene glycol and 2 ml of water. This solution, after cooling is acidified with hydrochloric acid to pH 5, and the crystals formed are drained and dried and then washed with acetone to give 5 g of 4'-[(7-n-Butyl-5-methyl-2-oxo-2,3-dihydro-1,2,4-triazolo[1,5-c]pyrimidin-8-yl}methyl]-2-biphenylcarboxylic acid in the form of crystals of melting point 210°-211° C.

Provenance & Evidence