HCID 178440259, compound → HCID 178440189, compound

Participants

Reaction Steps

29 g of 6-n-propyl-2-methylthio-4-hydroxy-5-[(2'-cyano-4-biphenylyl)methyl]pyrimidine, prepared in Example 101, are dissolved in 250 ml of diglyme, and 60 g of Raney nickel are added. The mixture is heated to reflux for 3 hours. The catalyst is filtered off and washed with ethanol, the filtrate is evaporated under vacuum and the residue is chromatographed on silica gel in a 2:8 acetone/chloroform eluent to give 14.2 g of 6-n-propyl-4-hydroxy-5-[(2'-cyano-4-biphenylyl)methyl]pyrimidine in the form of crystals of melting point 158° C.

Provenance & Evidence