反应详情

24.5 g of 2-(4-methylphenyl)-3-cyanothiophene, prepared in E), are dissolved in 200 ml of carbon tetrachloride. 21.9 g of N-bromosuccinimide are added, as well as 0.1 g of benzoyl peroxide. The mixture is heated to reflux for 24 hours. The crystals of succinimide are filtered off and the solvent is evaporated off under vacuum. The residue is taken up in a mixture of hexane and ethyl acetate and the solution is kept in a freezer for 24 hours. The crystals formed are drained to give 14 g of 4-(3-cyano-2-thienyl)benzyl bromide in the form of crystals of melting point 80° C.

1. temperatureThe mixture is heated
2. temperatureto reflux for 24 hours
3. filtrationThe crystals of succinimide are filtered off
4. customthe solvent is evaporated off under vacuum
5. additionThe residue is taken up in a mixture of hexane and ethyl acetate
6. customThe crystals formed