Dimethylformamide → HCID 18958827, compound

Participants

Reaction Steps

1.5 g of 6-n-propyl-2-methyl-4-hydroxy-5-{[2'-(4,4-dimethyl-2-oxazolinyl)-4-biphenylyl]methyl}pyrimidine, prepared in Example 184, are dissolved in 3 ml of thionyl chloride. 0.1 ml of dimethylformamide is added and the mixture is stirred for 1 hour at room temperature. The thionyl chloride is evaporated off under vacuum without heating, and the residue is washed with ether, then alkalinised with ammonium hydroxide solution and washed with water. The ether phase is evaporated under vacuum to give 0.6 g of 6-n-propyl-2-methyl-4-chloro-5-{[2'-(4,4-dimethyl-2-oxazolinyl)-4-biphenylyl]methyl}pyrimidine in the form of an oil, which is used without further purification for the next step.

Provenance & Evidence