Bromine → HCID 18958836, compound

HRID 1708425Notes

Reaction equation

HRID 1708425 reaction equation
[CH2:1]([C:4]1[N:9]=[C:8]([CH3:10])[N:7]2[NH:11][C:12](=[O:14])[N:13]=[C:6]2[CH:5]=1)[CH2:2][CH3:3].C([O-])(=O)C.[Na+].[Br:20]Br>C(O)(=O)C>[CH2:1]([C:4]1[N:9]=[C:8]([CH3:10])[N:7]2[NH:11][C:12](=[O:14])[N:13]=[C:6]2[C:5]=1[Br:20])[CH2:2][CH3:3]

Participants

5

Reactant 3

HCID 24408BromineHCID 517045Sodium AcetateHCID 18958839HCID 18958839, compound

Product 1

HCID 18958836HCID 18958836, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent2×

Procedure

A solution of 10 g of 7-n-propyl-5-methyl-1,2,4-triazolo[1,5-c]pyrimidin-2(3H)-one, prepared in Example 193, in 120 ml of acetic acid containing 12 g of sodium acetate, and to which a solution of 2.6 ml of bromine in 50 ml of acetic acid has been added dropwise, is stirred at room temperature for 3 hours. The reaction mixture is then concentrated under vacuum and thereafter treated with water. The crystals formed are drained, washed with water and dried. 7 g of 7-n-propyl-5-methyl-8-bromo-1,2,4-triazolo[1,5-c]pyrimidin-2(3H)-one are thereby obtained in the form of crystals of melting point 221° C.

Workup

  1. concentrationThe reaction mixture is then concentrated under vacuum
  2. additiontreated with water
  3. customThe crystals formed
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-99705526a5614bdcaf44b2c90717e0dd
Source dataset
uspto-grants-1994_10
Patent number
US05358950

Reaction notes

Loading…